Royal Caribbean Cruises from San Diego

Royal Caribbean is expanding its departures from San Diego with several cruises to Mexico. See the details below.

The Serenade of the Seas is the Royal Caribbean ship sailing from San Diego. Features include a pool with retractable glass roof, signature 40 foot rock-climbing wall, live entertainment, spa, Vibeology, game shows, pool parties, outdoor movie nights, kids programs, and casino. Dining options include Chef's Table, Cafe' Latte-tudes, Windjammer buffet, Izumi, Chops Grille, Giovanni's Table, Park Cafe, and the main dining room.

Mexico

2-night Mexico cruise on the Serenade of the Seas. Round-trip from San Diego to Ensenada (Mexico).
• 2026 departure: October 2.

3-night Mexico cruise on the Serenade of the Seas. Round-trip from San Diego to Ensenada (Mexico).
• 2026 departures: October 15, December 3, December 10.
• 2027 departures: January 14, January 21, February 4, February 11, February 18, February 25, March 11, March 18, March 25, April 8, April 15.

4-night Mexico cruise on the Serenade of the Seas. Round-trip from San Diego to Catalina Island (California) and Ensenada (Mexico).
• 2026 departures: October 11, November 29, December 6.
• 2027 departures: January 10, January 17, January 24, February 7, February 14, February 21, March 7, March 14, March 21, April 4, April 11, April 18.

7-night Mexico cruise on the Serenade of the Seas. Round-trip from San Diego to Ensenada (Mexico), Cabo San Lucas (Mexico) and Mazatlan (Mexico).
• 2026 departures: November 1, November 8.
• 2027 departures: February 28.

7-night Mexico cruise on the Serenade of the Seas. Round-trip from San Diego to Cabo San Lucas (Mexico), Mazatlan (Mexico) and La Paz (Mexico).
• 2026 departures: November 22, December 20, December 27.
• 2027 departures: January 28.

7-night Mexico cruise on the Serenade of the Seas. Round-trip from San Diego to La Paz (Mexico), Cabo San Lucas (Mexico) and Ensenada (Mexico).
• 2026 departures: October 4, October 18, October 25, November 15.
• 2027 departures: January 3, March 28.

7-night Mexico cruise on the Serenade of the Seas. Round-trip from San Diego to Catalina Island (California), Ensenada (Mexico) and Cabo San Lucas (Mexico)(overnight).
• 2026 departures: December 13.

Panama Canal

13-night Panama Canal cruise on the Serenade of the Seas. One-way from San Diego to Miami (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2025 departure: September 19.

San Diego Harbor Cruises

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